7C04

Crystal structure of human Trap1 with DN203492

Summary for 7C04

• Entry DOI: 10.2210/pdb7c04/pdb
• Descriptor: Heat shock protein 75 kDa, mitochondrial, 4-chloranyl-1-[[2-methoxy-4-(trifluoromethyl)phenyl]methyl]pyrazolo[3,4-d]pyrimidin-6-amine (3 entities in total)
• Functional Keywords: trap1, selectivity, mitochondria, hsp90, anticancer, drug, chaperone
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 26137.58

Authors

Kim, D.,Kim, D.,Kim, S.Y.,Lee, J.H.,Kang, B.H.,Kang, S.,Lee, C. (deposition date: 2020-04-30, release date: 2020-07-08, Last modification date: 2023-11-29)

• Primary citation: Kim, D.,Kim, S.Y.,Kim, D.,Yoon, N.G.,Yun, J.,Hong, K.B.,Lee, C.,Lee, J.H.,Kang, B.H.,Kang, S.; Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models.; Bioorg.Chem., 101:103901-103901, 2020; PubMed: 32590225; DOI: 10.1016/j.bioorg.2020.103901

Experimental method

X-RAY DIFFRACTION (1.7 Å)