7BUQ

mcGAS bound with 23-cGAMP

Summary for 7BUQ

• Entry DOI: 10.2210/pdb7buq/pdb
• Related: 7BUJ
• Descriptor: Cyclic GMP-AMP synthase, ZINC ION, cGAMP, ... (4 entities in total)
• Functional Keywords: mcgas, activator, inverted-orientation, metal-ion binding protein, immune system
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 2
• Total formula weight: 118079.37

Authors

Wang, B.,Su, X.D. (deposition date: 2020-04-07, release date: 2020-09-02, Last modification date: 2023-11-29)

• Primary citation: Zhao, Z.,Ma, Z.,Wang, B.,Guan, Y.,Su, X.D.,Jiang, Z.; Mn2+Directly Activates cGAS and Structural Analysis Suggests Mn2+Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.; Cell Rep, 32:108053-108053, 2020; PubMed: 32814054; DOI: 10.1016/j.celrep.2020.108053

Experimental method

X-RAY DIFFRACTION (3.091 Å)