7BUC

Crystal structure of EHMT2 SET domain in complex with compound 13

Summary for 7BUC

Entry DOI	10.2210/pdb7buc/pdb
Descriptor	Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
Functional Keywords	protein-small molecule inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	67208.86
Authors	Suzuki, M.,Mizuno, M.,Katayama, K. (deposition date: 2020-04-06, release date: 2020-11-11, Last modification date: 2023-11-29)
Primary citation	Katayama, K.,Ishii, K.,Tsuda, E.,Yotsumoto, K.,Hiramoto, K.,Suzuki, M.,Yasumatsu, I.,Igarashi, W.,Torihata, M.,Ishiyama, T.,Katagiri, T. Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines. Bioorg.Med.Chem.Lett., 30:127475-127475, 2020 Cited by PubMed: 32781218 DOI: 10.1016/j.bmcl.2020.127475 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation