7BOS

Human SIRT2 in complex with myristoyl thiourea inhibitor, No.13

Summary for 7BOS

• Entry DOI: 10.2210/pdb7bos/pdb
• Related PRD ID: PRD_002361
• Descriptor: NAD-dependent protein deacetylase sirtuin-2, Myristoyl thiourea inhibitor, No.13, ZINC ION, ... (5 entities in total)
• Functional Keywords: nad-dependent deacetylase, deacylase, inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 34089.78

Authors

Kudo, N.,Olsen, C.A.,Minoru, Y. (deposition date: 2020-03-19, release date: 2021-03-24, Last modification date: 2023-11-29)

• Primary citation: Nielsen, A.L.,Rajabi, N.,Kudo, N.,Lundo, K.,Moreno-Yruela, C.,Baek, M.,Fontenas, M.,Lucidi, A.,Madsen, A.S.,Yoshida, M.,Olsen, C.A.; Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration.; Rsc Chem Biol, 2:612-626, 2021; PubMed: 34458803; DOI: 10.1039/d0cb00036a

Experimental method

X-RAY DIFFRACTION (1.7 Å)