7BGC

human butyrylcholinesterase in complex with a tacrine-methylanacardate hybrid inhibitor

Summary for 7BGC

• Entry DOI: 10.2210/pdb7bgc/pdb
• Related: 1p0i
• Descriptor: Cholinesterase, SULFATE ION, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: inhibitor, alzheimer, butyrylcholinesterase, tacrine, anacardic acid, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 64038.95

Authors

Nachon, F.,Salerno, A.,Bolognesi, M.L. (deposition date: 2021-01-06, release date: 2021-04-28, Last modification date: 2024-01-31)

• Primary citation: Rossi, M.,Freschi, M.,de Camargo Nascente, L.,Salerno, A.,de Melo Viana Teixeira, S.,Nachon, F.,Chantegreil, F.,Soukup, O.,Prchal, L.,Malaguti, M.,Bergamini, C.,Bartolini, M.,Angeloni, C.,Hrelia, S.,Soares Romeiro, L.A.,Bolognesi, M.L.; Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease.; J.Med.Chem., 64:4972-4990, 2021; PubMed: 33829779; DOI: 10.1021/acs.jmedchem.1c00048

Experimental method

X-RAY DIFFRACTION (2.4 Å)