7B9M

Cys-45-tethered stabilizer 3 of 14-3-3(sigma)/ERa PPI

Summary for 7B9M

Entry DOI	10.2210/pdb7b9m/pdb
Descriptor	14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	protein-protein interaction; stabilization; hub protein; transcription factor, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	27803.81
Authors	Sijbesma, E.,Ottmann, C. (deposition date: 2020-12-14, release date: 2021-07-07, Last modification date: 2024-01-31)
Primary citation	Sijbesma, E.,Hallenbeck, K.K.,Andrei, S.A.,Rust, R.R.,Adriaans, J.M.C.,Brunsveld, L.,Arkin, M.R.,Ottmann, C. Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12:976-982, 2021 Cited by PubMed: 34136078 DOI: 10.1021/acsmedchemlett.1c00088 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation