7B63

Structure of NUDT15 in complex with TH7755

Summary for 7B63

• Entry DOI: 10.2210/pdb7b63/pdb
• Descriptor: Probable 8-oxo-dGTP diphosphatase NUDT15, (R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, nucleoside triphosphate pyrophosphohydrolase, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 38203.31

Authors

Rehling, D.,Stenmark, P. (deposition date: 2020-12-07, release date: 2021-03-24, Last modification date: 2024-01-31)

• Primary citation: Rehling, D.,Zhang, S.M.,Jemth, A.S.,Koolmeister, T.,Throup, A.,Wallner, O.,Scaletti, E.,Moriyama, T.,Nishii, R.,Davies, J.,Desroses, M.,Rudd, S.G.,Scobie, M.,Homan, E.,Berglund, U.W.,Yang, J.J.,Helleday, T.,Stenmark, P.; Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.; J.Biol.Chem., 296:100568-100568, 2021; PubMed: 33753169; DOI: 10.1016/j.jbc.2021.100568

Experimental method

X-RAY DIFFRACTION (1.6 Å)