7B2X

Crystal structure of human 5' exonuclease Appollo H61Y variant

Summary for 7B2X

Entry DOI	10.2210/pdb7b2x/pdb
Descriptor	5' exonuclease Apollo, NICKEL (II) ION (3 entities in total)
Functional Keywords	dclre1b, snm1b, exonuclease, apollo, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	38197.55
Authors	Newman, J.A.,Baddock, H.T.,Mukhopadhyay, S.M.M.,Burgess-Brown, N.A.,von Delft, F.,Arrowshmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2020-11-28, release date: 2021-01-20, Last modification date: 2024-01-31)
Primary citation	Baddock, H.T.,Newman, J.A.,Yosaatmadja, Y.,Bielinski, M.,Schofield, C.J.,Gileadi, O.,McHugh, P.J. A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family. Nucleic Acids Res., 49:9294-9309, 2021 Cited by PubMed: 34387694 DOI: 10.1093/nar/gkab692 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation