7AR4

Crystal structure of beta-catenin in complex with cyclic peptide inhibitor

This is a non-PDB format compatible entry.

Summary for 7AR4

• Entry DOI: 10.2210/pdb7ar4/pdb
• Descriptor: Catenin beta-1, Cadherin-1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (5 entities in total)
• Functional Keywords: wnt signaling, peptide inhibitor, protein-peptide interaction, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 60401.35

Authors

Wendt, M.,Pearce, N.M.,Grossmann, T.N.,Hennig, S. (deposition date: 2020-10-23, release date: 2021-04-07, Last modification date: 2024-01-31)

• Primary citation: Wendt, M.,Bellavita, R.,Gerber, A.,Efrem, N.L.,van Ramshorst, T.,Pearce, N.M.,Davey, P.R.J.,Everard, I.,Vazquez-Chantada, M.,Chiarparin, E.,Grieco, P.,Hennig, S.,Grossmann, T.N.; Bicyclic beta-Sheet Mimetics that Target the Transcriptional Coactivator beta-Catenin and Inhibit Wnt Signaling.; Angew.Chem.Int.Ed.Engl., 60:13937-13944, 2021; PubMed: 33783110; DOI: 10.1002/anie.202102082

Experimental method

X-RAY DIFFRACTION (2.6 Å)