7APG

Crystal structure of JAK3 in complex with FM587 (compound 9a)

Summary for 7APG

Entry DOI	10.2210/pdb7apg/pdb
Descriptor	Tyrosine-protein kinase JAK3, ~{N}-[3-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide, 1-phenylurea, ... (5 entities in total)
Functional Keywords	kinase, jak3, inhibitor, covalent inhibitor, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	136392.19
Authors	Chaikuad, A.,Forster, M.,Gehringer, M.,Laufer, S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-10-16, release date: 2020-12-02, Last modification date: 2024-01-31)
Primary citation	Forster, M.,Liang, X.J.,Schroder, M.,Gerstenecker, S.,Chaikuad, A.,Knapp, S.,Laufer, S.,Gehringer, M. Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK. Int J Mol Sci, 21:-, 2020 Cited by PubMed: 33291717 DOI: 10.3390/ijms21239269 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation