7ANA

A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium (BT1622-S1_20)

This is a non-PDB format compatible entry.

Summary for 7ANA

• Entry DOI: 10.2210/pdb7ana/pdb
• Related: 7ALL 7ANI 7PV0 7PV1
• Descriptor: N-acetylgalactosamine-6-sulfatase, 2-acetamido-2-deoxy-alpha-D-galactopyranose, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: carbohydrate sulfatase, mucin, microbiome, bacteroides, hydrolase
• Biological source: Bacteroides thetaiotaomicron VPI-5482
• Total number of polymer chains: 2
• Total formula weight: 114457.51

Authors

Sofia de Jesus Vaz Luis, A.,Basle, A.,Martens, E.C.,Cartmell, A. (deposition date: 2020-10-11, release date: 2021-11-10)

• Primary citation: Luis, A.S.,Jin, C.,Pereira, G.V.,Glowacki, R.W.P.,Gugel, S.R.,Singh, S.,Byrne, D.P.,Pudlo, N.A.,London, J.A.,Basle, A.,Reihill, M.,Oscarson, S.,Eyers, P.A.,Czjzek, M.,Michel, G.,Barbeyron, T.,Yates, E.A.,Hansson, G.C.,Karlsson, N.G.,Cartmell, A.,Martens, E.C.; A single sulfatase is required to access colonic mucin by a gut bacterium.; Nature, 598:332-337, 2021; PubMed: 34616040; DOI: 10.1038/s41586-021-03967-5

Experimental method

X-RAY DIFFRACTION (2.3 Å)