7AMG
IL-17A in complex with small molecule modulators
Summary for 7AMG
Entry DOI | 10.2210/pdb7amg/pdb |
Related | 7AMA |
Descriptor | Interleukin-17A, (3~{R})-4-[4-[[(2~{S})-2-[[2,2-bis(fluoranyl)-2-phenyl-ethanoyl]amino]-3-(2-chlorophenyl)propanoyl]amino]phenyl]-3-[[(2~{S})-3-methyl-2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethanoylamino]butanoyl]amino]butanoic acid (3 entities in total) |
Functional Keywords | interleukin il-17a inhibitor receptor, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 52289.99 |
Authors | Hakansson, M.,Kimbung, R.,Logan, D.,Walse, U.B.,de Groot, M.J.,Andrews, M.D.,Dack, K.N.,Lambert, M. (deposition date: 2020-10-08, release date: 2022-04-20, Last modification date: 2024-01-31) |
Primary citation | Andrews, M.D.,Dack, K.N.,de Groot, M.J.,Lambert, M.,Sennbro, C.J.,Larsen, M.,Stahlhut, M. Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases. J.Med.Chem., 65:8828-8842, 2022 Cited by PubMed: 35767390DOI: 10.1021/acs.jmedchem.2c00422 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.18 Å) |
Structure validation
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