7AB0

Apo crystal structure of the MerTK kinase domain

Summary for 7AB0

Entry DOI	10.2210/pdb7ab0/pdb
Related	7AAX 7AAY 7AAZ
Descriptor	Tyrosine-protein kinase Mer, CHLORIDE ION (3 entities in total)
Functional Keywords	tyrosine kinase, apo, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34559.02
Authors	Pflug, A.,Schimpl, M.,McCoull, W.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J. (deposition date: 2020-09-05, release date: 2020-10-28, Last modification date: 2024-01-31)
Primary citation	Pflug, A.,Schimpl, M.,Nissink, J.W.M.,Overman, R.C.,Rawlins, P.B.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J.,McCoull, W. A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Biochem.J., 477:4443-4452, 2020 Cited by PubMed: 33119085 DOI: 10.1042/BCJ20200735 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation