7A6T

Crystal Structure of Asn173Ser variant of Human Deoxyhypusine Synthase in complex with NAD and spermidine

Summary for 7A6T

Entry DOI	10.2210/pdb7a6t/pdb
Descriptor	Deoxyhypusine synthase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SPERMIDINE, ... (7 entities in total)
Functional Keywords	deoxyhypusine synthase, hypusination, hypusine, translation, neurodegeneration, spermidine dhps deficiency, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	84191.89
Authors	Wator, E.,Wilk, P.,Grudnik, P. (deposition date: 2020-08-26, release date: 2022-03-23, Last modification date: 2024-02-07)
Primary citation	Wator, E.,Wilk, P.,Biela, A.,Rawski, M.,Zak, K.M.,Steinchen, W.,Bange, G.,Glatt, S.,Grudnik, P. Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders. Nat Commun, 14:1698-1698, 2023 Cited by PubMed: 36973244 DOI: 10.1038/s41467-023-37305-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation