7A54

Two copies of the catalytic domain of NanA sialidase from Streptococcus pneumoniae juxtaposed in the P212121 space group, in complex with DANA

Summary for 7A54

Entry DOI	10.2210/pdb7a54/pdb
Descriptor	Sialidase A, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID (3 entities in total)
Functional Keywords	sialidase, catalytic domain, dana, structural protein
Biological source	Streptococcus pneumoniae
Total number of polymer chains	2
Total formula weight	112865.70
Authors	Bridot, C.,Bouckaert, J. (deposition date: 2020-08-20, release date: 2020-11-18, Last modification date: 2024-01-31)
Primary citation	Assailly, C.,Bridot, C.,Saumonneau, A.,Lottin, P.,Roubinet, B.,Krammer, E.M.,Francois, F.,Vena, F.,Landemarre, L.,Alvarez Dorta, D.,Deniaud, D.,Grandjean, C.,Tellier, C.,Pascual, S.,Montembault, V.,Fontaine, L.,Daligault, F.,Bouckaert, J.,Gouin, S.G. *Polyvalent Transition-State Analogues of Sialyl Substrates Strongly Inhibit Bacterial Sialidases.** Chemistry, 27:3142-3150, 2021 Cited by PubMed: 33150981 DOI: 10.1002/chem.202004672 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation