7A1L
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-methyl-2-oxoglutarate
Summary for 7A1L
| Entry DOI | 10.2210/pdb7a1l/pdb |
| Descriptor | Hypoxia-inducible factor 1-alpha inhibitor, (3~{S})-3-methyl-2-oxidanylidene-pentanedioic acid, ZINC ION, ... (5 entities in total) |
| Functional Keywords | hypoxia-inducible factor asparagine hydroxylase, dioxygenase, oxidoreductase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 40938.07 |
| Authors | Nakashima, Y.,Brewitz, L.,Schofield, C.J. (deposition date: 2020-08-13, release date: 2021-08-25, Last modification date: 2024-01-31) |
| Primary citation | Nakashima, Y.,Brewitz, L.,Tumber, A.,Salah, E.,Schofield, C.J. 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nat Commun, 12:6478-6478, 2021 Cited by PubMed: 34759269DOI: 10.1038/s41467-021-26673-2 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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