7A0L

Joint neutron/X-ray room temperature structure of perdeuterated Aspergillus flavus urate oxidase in complex with the 8-azaxanthine inhibitor and catalytic water bound in the peroxo hole

Summary for 7A0L

Entry DOI	10.2210/pdb7a0l/pdb
Descriptor	Uricase, 8-AZAXANTHINE, SODIUM ION, ... (4 entities in total)
Functional Keywords	cofactor-free oxidase, inhibitor, catalytic water, dioxygen binding, oxidoreductase
Biological source	Aspergillus flavus
Total number of polymer chains	1
Total formula weight	34464.83
Authors	McGregor, L.,Bui, S.,Blakeley, M.P.,Steiner, R.A. (deposition date: 2020-08-09, release date: 2020-12-09, Last modification date: 2021-02-10)
Primary citation	McGregor, L.,Foldes, T.,Bui, S.,Moulin, M.,Coquelle, N.,Blakeley, M.P.,Rosta, E.,Steiner, R.A. Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis. Iucrj, 8:46-59, 2021 Cited by PubMed: 33520242 DOI: 10.1107/S2052252520013615 PDB entries with the same primary citation
Experimental method	NEUTRON DIFFRACTION (2.1 Å) X-RAY DIFFRACTION (1.33 Å)

Structure validation