7MEQ

Crystal structure of human TMPRSS2 in complex with Nafamostat

Summary for 7MEQ

Entry DOI	10.2210/pdb7meq/pdb
Descriptor	Transmembrane protease serine 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-carbamimidamidobenzoic acid, ... (5 entities in total)
Functional Keywords	covid19, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	44496.89
Authors	Fraser, B.,Beldar, S.,Hutchinson, A.,Li, Y.,Seitova, A.,Edwards, A.M.,Benard, F.,Arrowsmith, C.H.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2021-04-07, release date: 2021-04-21, Last modification date: 2023-10-18)
Primary citation	Fraser, B.J.,Beldar, S.,Seitova, A.,Hutchinson, A.,Mannar, D.,Li, Y.,Kwon, D.,Tan, R.,Wilson, R.P.,Leopold, K.,Subramaniam, S.,Halabelian, L.,Arrowsmith, C.H.,Benard, F. Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation. Nat.Chem.Biol., 18:963-971, 2022 Cited by PubMed: 35676539 DOI: 10.1038/s41589-022-01059-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation