7MEQ

Crystal structure of human TMPRSS2 in complex with Nafamostat

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Transmembrane protease serine 2	polymer	395	43893.3	1	UniProt (O15393) Pfam (PF15494) Pfam (PF00089)	Homo sapiens (Human)	Serine protease 10
2	B (B)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
3	C (A)	4-carbamimidamidobenzoic acid	non-polymer		179.2	1	Chemie (GBS)
4	D, E, F (A)	UNKNOWN ATOM OR ION	non-polymer			3	Chemie (UNX)
5	G (A)	water	water		18.0	118	Chemie (HOH)

Sequence modifications

A: 109 - 492 (UniProt: O15393)

PDB	External Database	Details
Asp 251	Ser 250	conflict
Asp 252	Ser 251	conflict
-	Arg 252	deletion
Asp 253	Gln 253	conflict
Asp 254	Ser 254	conflict
Lys 255	Arg 255	conflict
Glu 493	-	expression tag
Phe 494	-	expression tag
Val 495	-	expression tag
Glu 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag
His 502	-	expression tag
His 503	-	expression tag
His 504	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43893.3
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	4
	Total formula weight	179.2
All*	Total formula weight	44496.9

*Water molecules are not included.