6ZYA
Extended human uromodulin filament core at 3.5 A resolution
Summary for 6ZYA
Entry DOI | 10.2210/pdb6zya/pdb |
Related | 6SZ5 |
EMDB information | 11388 |
Descriptor | Uromodulin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | uromodulin, umod, thp, immunoglobulin-like fold, tamm-horsfall protein, glycoprotein, zp module, zona pellucida, fold complementation, beta-strand complementation, cryosparc, filament, soluble adhesion antagonist, antimicrobial protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 71481.19 |
Authors | Stanisich, J.J.,Zyla, D.,Afanasyev, P.,Xu, J.,Pilhofer, M.,Boeringer, D.,Glockshuber, R. (deposition date: 2020-07-31, release date: 2020-09-02) |
Primary citation | Stanisich, J.J.,Zyla, D.S.,Afanasyev, P.,Xu, J.,Kipp, A.,Olinger, E.,Devuyst, O.,Pilhofer, M.,Boehringer, D.,Glockshuber, R. The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism. Elife, 9:-, 2020 Cited by PubMed: 32815518DOI: 10.7554/eLife.60265 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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