6ZWE

Crystal structure of human acetylcholinesterase in complex with ((6-((2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienamido)hexyl)triphenylphosphonium bromide)

Summary for 6ZWE

Entry DOI	10.2210/pdb6zwe/pdb
Descriptor	Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	human acetylcholinesterase, piperine derivative, mitochondria, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	123948.93
Authors	Da Silva, O.,Dias, J.,Nachon, F.,Brazzolotto, X. (deposition date: 2020-07-28, release date: 2021-06-09, Last modification date: 2024-01-31)
Primary citation	Chavarria, D.,Da Silva, O.,Benfeito, S.,Barreiro, S.,Garrido, J.,Cagide, F.,Soares, P.,Remiao, F.,Brazzolotto, X.,Nachon, F.,Oliveira, P.J.,Dias, J.,Borges, F. Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases. Antioxidants (Basel), 10:-, 2021 Cited by PubMed: 33672269 DOI: 10.3390/antiox10020329 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation