6ZU4
Human Sirt6 13-308 in complex with ADP-ribose and the activator fluvastatin
Summary for 6ZU4
Entry DOI | 10.2210/pdb6zu4/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (7 entities in total) |
Functional Keywords | deacylase, activator, allosteric, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 69972.86 |
Authors | You, W.,Steegborn, C. (deposition date: 2020-07-21, release date: 2020-11-18, Last modification date: 2024-01-31) |
Primary citation | You, W.,Steegborn, C. Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin. Acs Med.Chem.Lett., 11:2285-2289, 2020 Cited by PubMed: 33214841DOI: 10.1021/acsmedchemlett.0c00407 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.46 Å) |
Structure validation
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