6ZHC

PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL

This is a non-PDB format compatible entry.

Summary for 6ZHC

• Entry DOI: 10.2210/pdb6zhc/pdb
• Descriptor: von Hippel-Lindau disease tumor suppressor, Elongin-B, Elongin-C, ... (9 entities in total)
• Functional Keywords: protac complex, targeted degradation, ubiquitin ligase, bifunctional ligand, e3 ligase, bcl-xl, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 70560.51

Authors

Chung, C. (deposition date: 2020-06-22, release date: 2020-08-05, Last modification date: 2024-01-24)

• Primary citation: Chung, C.W.,Dai, H.,Fernandez, E.,Tinworth, C.P.,Churcher, I.,Cryan, J.,Denyer, J.,Harling, J.D.,Konopacka, A.,Queisser, M.A.,Tame, C.J.,Watt, G.,Jiang, F.,Qian, D.,Benowitz, A.B.; Structural Insights into PROTAC-Mediated Degradation of Bcl-xL.; Acs Chem.Biol., 15:2316-2323, 2020; PubMed: 32697072; DOI: 10.1021/acschembio.0c00266

Experimental method

X-RAY DIFFRACTION (1.92 Å)