6ZDM

Crystal structure of human heparanase in complex with a N',6O'-bis-sulfated 4-methylumbelliferyl heparan sulfate disaccharide

This is a non-PDB format compatible entry.

Summary for 6ZDM

• Entry DOI: 10.2210/pdb6zdm/pdb
• Descriptor: Heparanase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (7 entities in total)
• Functional Keywords: heparanase, substrate, fluorogenic, heparan sulfate, poised, 4-methylumbelliferyl, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 53713.26

Authors

Wu, L.,Davies, G.J. (deposition date: 2020-06-14, release date: 2020-10-21, Last modification date: 2024-01-24)

• Primary citation: Wu, L.,Wimmer, N.,Davies, G.J.,Ferro, V.; Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide.; Chem.Commun.(Camb.), 56:13780-13783, 2020; PubMed: 33073275; DOI: 10.1039/d0cc05932c

Experimental method

X-RAY DIFFRACTION (1.714 Å)