6Z86

human GTP cyclohydrolase I in complex with 7-deaza-GTP

Summary for 6Z86

Entry DOI	10.2210/pdb6z86/pdb
Descriptor	GTP cyclohydrolase 1, ZINC ION, 7-deaza-GTP, ... (4 entities in total)
Functional Keywords	gtp cyclohydrolase i, ec:3.5.4.16, tetrahydrobiopterin (bh4) synthesis, cytosol, zinc ion binding, hydrolase activity, metal ion binding, nucleotide binding, allosteric inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	20
Total formula weight	518250.42
Authors	Ebenhoch, R.,Nar, H. (deposition date: 2020-06-02, release date: 2020-12-09, Last modification date: 2024-01-24)
Primary citation	Ebenhoch, R.,Prinz, S.,Kaltwasser, S.,Mills, D.J.,Meinecke, R.,Rubbelke, M.,Reinert, D.,Bauer, M.,Weixler, L.,Zeeb, M.,Vonck, J.,Nar, H. A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117:31838-31849, 2020 Cited by PubMed: 33229582 DOI: 10.1073/pnas.2013473117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.206 Å)

Structure validation