6Z48

Crystal structure of Thrombin in complex with macrocycle X1vE

Summary for 6Z48

• Entry DOI: 10.2210/pdb6z48/pdb
• Descriptor: Thrombin light chain, Thrombin heavy chain, SODIUM ION, ... (5 entities in total)
• Functional Keywords: serine protease, blood clotting factor, inhibition, macrocycle, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 138103.82

Authors

Angelini, A.,Habeshian, S.,Heinis, C.,Cendron, L. (deposition date: 2020-05-23, release date: 2022-06-01, Last modification date: 2024-01-24)

• Primary citation: Habeshian, S.,Merz, M.L.,Sangouard, G.,Mothukuri, G.K.,Schuttel, M.,Bognar, Z.,Diaz-Perlas, C.,Vesin, J.,Bortoli Chapalay, J.,Turcatti, G.,Cendron, L.,Angelini, A.,Heinis, C.; Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale.; Nat Commun, 13:3823-3823, 2022; PubMed: 35780129; DOI: 10.1038/s41467-022-31428-8

Experimental method

X-RAY DIFFRACTION (2.27 Å)