6Z2V

CLK3 A319V mutant bound with beta-carboline KH-CARB13 (Cpd 3)

Summary for 6Z2V

Entry DOI	10.2210/pdb6z2v/pdb
Descriptor	Dual specificity protein kinase CLK3, (4~{S})-7,8-bis(chloranyl)-9-methyl-1-oxidanylidene-spiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	inhibitor, complex, clk3, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42810.87
Authors	Schroeder, M.,Chaikuad, A.,Bracher, F.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-05-18, release date: 2020-07-29, Last modification date: 2024-01-24)
Primary citation	Schroder, M.,Bullock, A.N.,Fedorov, O.,Bracher, F.,Chaikuad, A.,Knapp, S. DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity. J.Med.Chem., 63:10224-10234, 2020 Cited by PubMed: 32787076 DOI: 10.1021/acs.jmedchem.0c00898 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation