6YXM

Crystal structure of ACPA 1F2 in complex with CII-C-39-CIT

This is a non-PDB format compatible entry.

Summary for 6YXM

• Entry DOI: 10.2210/pdb6yxm/pdb
• Descriptor: CII-C-39-CIT, ACPA 1F2 Fab fragment - heavy chain, ACPA 1F2 Fab fragment - light chain, ... (6 entities in total)
• Functional Keywords: anti-citrullinated protein antibody, collagen type ii, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 48560.01

Authors

Ge, C.,Holmdahl, R. (deposition date: 2020-05-03, release date: 2021-05-12, Last modification date: 2024-01-31)

• Primary citation: Kissel, T.,Ge, C.,Hafkenscheid, L.,Kwekkeboom, J.C.,Slot, L.M.,Cavallari, M.,He, Y.,van Schie, K.A.,Vergroesen, R.D.,Kampstra, A.S.B.,Reijm, S.,Stoeken-Rijsbergen, G.,Koeleman, C.,Voortman, L.M.,Heitman, L.H.,Xu, B.,Pruijn, G.J.M.,Wuhrer, M.,Rispens, T.,Huizinga, T.W.J.,Scherer, H.U.,Reth, M.,Holmdahl, R.,Toes, R.E.M.; Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation.; Sci Adv, 8:eabm1759-eabm1759, 2022; PubMed: 35138894; DOI: 10.1126/sciadv.abm1759

Experimental method

X-RAY DIFFRACTION (2.85 Å)