6YU1
CLK3 bound with beta-carboline KH-CARB13 (Cpd 3)
Summary for 6YU1
| Entry DOI | 10.2210/pdb6yu1/pdb |
| Descriptor | Dual specificity protein kinase CLK3, 1,2-ETHANEDIOL, PHOSPHATE ION, ... (6 entities in total) |
| Functional Keywords | inhibitor, complex, clk3, structural genomics, structural genomics consortium, sgc, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 87402.17 |
| Authors | Schroeder, M.,Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-04-25, release date: 2020-07-15, Last modification date: 2024-01-24) |
| Primary citation | Schroder, M.,Bullock, A.N.,Fedorov, O.,Bracher, F.,Chaikuad, A.,Knapp, S. DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity. J.Med.Chem., 63:10224-10234, 2020 Cited by PubMed: 32787076DOI: 10.1021/acs.jmedchem.0c00898 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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