6YRS
Structure of a new variant of GNCA ancestral beta-lactamase
Summary for 6YRS
Entry DOI | 10.2210/pdb6yrs/pdb |
Descriptor | ancestral beta-lactamase, ACETATE ION, TRIETHYLENE GLYCOL, ... (7 entities in total) |
Functional Keywords | hydrolase, antibiotic resistance, ancestral reconstructed |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 59679.80 |
Authors | Gavira, J.A.,Risso, V.,Martinez-Rodriguez, S.,Sanchez-Ruiz, J.M.,Modi, T.,Ozkan, S.B. (deposition date: 2020-04-20, release date: 2021-03-03, Last modification date: 2024-01-24) |
Primary citation | Modi, T.,Risso, V.A.,Martinez-Rodriguez, S.,Gavira, J.A.,Mebrat, M.D.,Van Horn, W.D.,Sanchez-Ruiz, J.M.,Banu Ozkan, S. Hinge-shift mechanism as a protein design principle for the evolution of beta-lactamases from substrate promiscuity to specificity. Nat Commun, 12:1852-1852, 2021 Cited by PubMed: 33767175DOI: 10.1038/s41467-021-22089-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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