6YPD

Crystal structure of AmpC from E. coli with Cyclic Boronate 3 (CB3 / APC308)

Summary for 6YPD

Entry DOI	10.2210/pdb6ypd/pdb
Descriptor	Beta-lactamase, (3~{S})-2,2-bis(oxidanyl)-3-(phenylmethylsulfanyl)-3,4-dihydro-1,2-benzoxaborinin-2-ium-8-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... (8 entities in total)
Functional Keywords	beta lactamase, antibiotic resistance, bicyclic boronate, hydrolase
Biological source	Escherichia coli K-12
Total number of polymer chains	1
Total formula weight	40434.46
Authors	Lang, P.A.,Brem, J.,Schofield, C.J. (deposition date: 2020-04-15, release date: 2020-06-24, Last modification date: 2024-01-24)
Primary citation	Lang, P.A.,Parkova, A.,Leissing, T.M.,Calvopina, K.,Cain, R.,Krajnc, A.,Panduwawala, T.D.,Philippe, J.,Fishwick, C.W.G.,Trapencieris, P.,Page, M.G.P.,Schofield, C.J.,Brem, J. Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C beta-Lactamase from Escherichia coli . Biomolecules, 10:-, 2020 Cited by PubMed: 32545682 DOI: 10.3390/biom10060899 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation