6YOX

14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-027

Summary for 6YOX

• Entry DOI: 10.2210/pdb6yox/pdb
• Related: 6QHL
• Descriptor: 14-3-3 protein sigma, p65pS45, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: 4-(methylsulfonyl)-benzaldehyde, covalent fragment, p65, 1433, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 29903.97

Authors

Wolter, M.,Ottmann, C. (deposition date: 2020-04-15, release date: 2020-09-23, Last modification date: 2024-01-24)

• Primary citation: Wolter, M.,Valenti, D.,Cossar, P.J.,Levy, L.M.,Hristeva, S.,Genski, T.,Hoffmann, T.,Brunsveld, L.,Tzalis, D.,Ottmann, C.; Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering.; Angew.Chem.Int.Ed.Engl., 59:21520-21524, 2020; PubMed: 32816380; DOI: 10.1002/anie.202008585

Experimental method

X-RAY DIFFRACTION (2.05 Å)