6YEO

Crystal structure of AmpC from E. coli with cyclic boronate 2

Summary for 6YEO

Entry DOI	10.2210/pdb6yeo/pdb
Descriptor	Beta-lactamase, (4~{R})-4-[[4-(aminomethyl)phenyl]carbonylamino]-3,3-bis(oxidanyl)-2-oxa-3-boranuidabicyclo[4.4.0]deca-1(10),6,8-triene-10-carboxylic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (8 entities in total)
Functional Keywords	beta lactamase, antibiotic resistance, bicyclic boronate, hydrolase
Biological source	Escherichia coli (strain K12)
Total number of polymer chains	4
Total formula weight	161109.13
Authors	Lang, P.A.,Schofield, C.J.,Brem, J. (deposition date: 2020-03-25, release date: 2020-06-24, Last modification date: 2024-01-24)
Primary citation	Lang, P.A.,Parkova, A.,Leissing, T.M.,Calvopina, K.,Cain, R.,Krajnc, A.,Panduwawala, T.D.,Philippe, J.,Fishwick, C.W.G.,Trapencieris, P.,Page, M.G.P.,Schofield, C.J.,Brem, J. Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C beta-Lactamase from Escherichia coli . Biomolecules, 10:-, 2020 Cited by PubMed: 32545682 DOI: 10.3390/biom10060899 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.037 Å)

Structure validation