6YE9

Small-molecule inhibitor of 14-3-3 protein-protein interactions

Summary for 6YE9

• Entry DOI: 10.2210/pdb6ye9/pdb
• Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, [2-[2-oxidanylidene-2-[(phenylmethyl)amino]ethoxy]phenyl]phosphonic acid, ... (4 entities in total)
• Functional Keywords: 14-3-3, inhibitor, protein-protein interaction, small molecule, structural protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 26937.09

Authors

Ottmann, C.,Visser, E.J. (deposition date: 2020-03-24, release date: 2021-03-31, Last modification date: 2024-01-24)

• Primary citation: Sijbesma, E.,Visser, E.J.,Plitzko, K.,Thiel, P.,Milroy, L.G.,Kaiser, M.,Brunsveld, L.,Ottmann, C.; Structure-based conversion of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)