6Y5M

Crystal structure of mouse Autotaxin in complex with compound 1a

Summary for 6Y5M

Entry DOI	10.2210/pdb6y5m/pdb
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	zinc binding hydrolase activity inhibitor, hydrolase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	1
Total formula weight	97920.19
Authors	Faller, M.,Zink, F. (deposition date: 2020-02-25, release date: 2020-11-18, Last modification date: 2024-01-24)
Primary citation	Thomson, C.G.,Le Grand, D.,Dowling, M.,Beattie, D.,Elphick, L.,Faller, M.,Freeman, M.,Hardaker, E.,Head, V.,Hemmig, R.,Hill, J.,Lister, A.,Pascoe, D.,Rieffel, S.,Shrestha, B.,Steward, O.,Zink, F. Development of autotaxin inhibitors: A series of tetrazole cinnamides. Bioorg.Med.Chem.Lett., 31:127663-127663, 2021 Cited by PubMed: 33160025 DOI: 10.1016/j.bmcl.2020.127663 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.011 Å)

Structure validation