6Y3C

Human COX-1 Crystal Structure

Summary for 6Y3C

• Entry DOI: 10.2210/pdb6y3c/pdb
• Descriptor: Prostaglandin G/H synthase 1, beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: cox-1, cyclooxygenase, peroxidase, prostaglandin, heme, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 68397.59

Authors

Miciaccia, M.,Belviso, B.D.,Iaselli, M.,Ferorelli, S.,Perrone, M.G.,Caliandro, R.,Scilimati, A. (deposition date: 2020-02-18, release date: 2020-02-26, Last modification date: 2024-01-24)

• Primary citation: Miciaccia, M.,Belviso, B.D.,Iaselli, M.,Cingolani, G.,Ferorelli, S.,Cappellari, M.,Loguercio Polosa, P.,Perrone, M.G.,Caliandro, R.,Scilimati, A.; Three-dimensional structure of human cyclooxygenase (hCOX)-1.; Sci Rep, 11:4312-4312, 2021; PubMed: 33619313; DOI: 10.1038/s41598-021-83438-z

Experimental method

X-RAY DIFFRACTION (3.361 Å)