6XXT

The crystal structure of hCA II in complex with a 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamide derivative.

Summary for 6XXT

Entry DOI	10.2210/pdb6xxt/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 4-[4-(phenylcarbonyl)piperazin-1-yl]carbonylbenzenesulfonamide, ... (5 entities in total)
Functional Keywords	protein-inhibitor adduct, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	30008.24
Authors	Di Fiore, A.,De Simone, G. (deposition date: 2020-01-28, release date: 2020-06-03, Last modification date: 2024-01-24)
Primary citation	Mancuso, F.,Di Fiore, A.,De Luca, L.,Angeli, A.,Monti, S.M.,De Simone, G.,Supuran, C.T.,Gitto, R. Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms. Acs Med.Chem.Lett., 11:1000-1005, 2020 Cited by PubMed: 32435417 DOI: 10.1021/acsmedchemlett.0c00062 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.05 Å)

Structure validation