6XVD

Crystal structure of complex of urokinase and a upain-1 variant(W3F) in pH7.4 condition

Summary for 6XVD

Entry DOI	10.2210/pdb6xvd/pdb
Descriptor	Urokinase-type plasminogen activator, upain-1-W3F (3 entities in total)
Functional Keywords	upain-1-w3f, urokinase, cyclic peptide inhibitor, peptide binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	29811.97
Authors	Xue, G.P.,Xie, X.,Zhou, Y.,Yuan, C.,Huang, M.D.,Jiang, L.G. (deposition date: 2020-01-21, release date: 2020-02-19, Last modification date: 2024-01-24)
Primary citation	Xue, G.,Xie, X.,Zhou, Y.,Yuan, C.,Huang, M.,Jiang, L. Insight to the residue in P2 position prevents the peptide inhibitor from being hydrolyzed by serine proteases. Biosci.Biotechnol.Biochem., 84:1153-1159, 2020 Cited by PubMed: 32019421 DOI: 10.1080/09168451.2020.1723405 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation