6XN9

Solution NMR structure of recifin, a cysteine-rich tyrosyl-DNA Phosphodiesterase I modulatory peptide from the marine sponge Axinella sp.

Summary for 6XN9

• Entry DOI: 10.2210/pdb6xn9/pdb
• NMR Information: BMRB: 30767
• Descriptor: Recifin modulatory peptide (1 entity in total)
• Functional Keywords: cystine-rich peptide, protein knot, tyrosyl-dna phosphodiesterase i inhibitor, marine natural product, toxin
• Biological source: Axinella sp. 1 TF-2017
• Total number of polymer chains: 1
• Total formula weight: 4924.44

Authors

Schroeder, C.I.,Rosengren, K.J.,O'Keefe, B.R. (deposition date: 2020-07-02, release date: 2021-02-10)

• Primary citation: Krumpe, L.R.H.,Wilson, B.A.P.,Marchand, C.,Sunassee, S.N.,Bermingham, A.,Wang, W.,Price, E.,Guszczynski, T.,Kelley, J.A.,Gustafson, K.R.,Pommier, Y.,Rosengren, K.J.,Schroeder, C.I.,O'Keefe, B.R.; Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I.; J.Am.Chem.Soc., 142:21178-21188, 2020; PubMed: 33263997; DOI: 10.1021/jacs.0c10418

Experimental method

SOLUTION NMR