6XKD

Structure of ligand-bound mouse cGAMP hydrolase ENPP1

Summary for 6XKD

Entry DOI	10.2210/pdb6xkd/pdb
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Mus musculus (Mouse)
Total number of polymer chains	2
Total formula weight	191818.79
Authors	Fernandez, D.,Li, L. (deposition date: 2020-06-26, release date: 2021-06-02, Last modification date: 2023-10-18)
Primary citation	Carozza, J.A.,Brown, J.A.,Bohnert, V.,Fernandez, D.,AlSaif, Y.,Mardjuki, R.E.,Smith, M.,Li, L. Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP. Cell Chem Biol, 27:1347-1358.e5, 2020 Cited by PubMed: 32726585 DOI: 10.1016/j.chembiol.2020.07.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation