6XDM

STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH AN ARYL KETONE INHIBITOR

Summary for 6XDM

Entry DOI	10.2210/pdb6xdm/pdb
Descriptor	Histone deacetylase 2, ZINC ION, CALCIUM ION, ... (7 entities in total)
Functional Keywords	histone deacetylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	132740.70
Authors	Klein, D.J.,Liu, J. (deposition date: 2020-06-11, release date: 2020-07-29, Last modification date: 2024-03-06)
Primary citation	Liu, J.,Kelly, J.,Yu, W.,Clausen, D.,Yu, Y.,Kim, H.,Duffy, J.L.,Chung, C.C.,Myers, R.W.,Carroll, S.,Klein, D.J.,Fells, J.,Holloway, M.K.,Wu, J.,Wu, G.,Howell, B.J.,Barnard, R.J.O.,Kozlowski, J.A. Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance. Acs Med.Chem.Lett., 11:1476-1483, 2020 Cited by PubMed: 32676157 DOI: 10.1021/acsmedchemlett.0c00302 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation