6XD7

KPC-2 N170A mutant bound to hydrolyzed ampicillin at 1.65 A

Summary for 6XD7

Entry DOI	10.2210/pdb6xd7/pdb
Descriptor	Carbapenem-hydrolyzing beta-lactamase KPC, (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	carbapenemase, beta-lactamase, antibiotic, hydrolase, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	31560.74
Authors	Pemberton, O.A.,Chen, Y. (deposition date: 2020-06-10, release date: 2020-12-09, Last modification date: 2023-10-18)
Primary citation	Mehta, S.C.,Furey, I.M.,Pemberton, O.A.,Boragine, D.M.,Chen, Y.,Palzkill, T. KPC-2 beta-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J.Biol.Chem., 296:100155-100155, 2020 Cited by PubMed: 33273017 DOI: 10.1074/jbc.RA120.015050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation