6XCD

Structure of the C. botulinum neurotoxin serotype A light chain protease in complex with covalent inhibitor 22

Summary for 6XCD

Entry DOI	10.2210/pdb6xcd/pdb
Descriptor	Botulinum neurotoxin type A, ZINC ION, N-hydroxy-7-sulfanylheptanamide, ... (4 entities in total)
Functional Keywords	covalent inhibitor, hydroxamate, toxin, toxin-inhibitor complex, toxin/inhibitor
Biological source	Clostridium botulinum
Total number of polymer chains	1
Total formula weight	50697.55
Authors	Tararina, M.A.,Allen, K.N. (deposition date: 2020-06-08, release date: 2021-06-09, Last modification date: 2023-10-18)
Primary citation	Lin, L.,Olson, M.E.,Sugane, T.,Turner, L.D.,Tararina, M.A.,Nielsen, A.L.,Kurbanov, E.K.,Pellett, S.,Johnson, E.A.,Cohen, S.M.,Allen, K.N.,Janda, K.D. Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A. J.Med.Chem., 63:11100-11120, 2020 Cited by PubMed: 32886509 DOI: 10.1021/acs.jmedchem.0c01006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation