6XA2

Structure of the tirandamycin C-bound P450 monooxygenase TamI

Summary for 6XA2

• Entry DOI: 10.2210/pdb6xa2/pdb
• Descriptor: TamI, PROTOPORPHYRIN IX CONTAINING FE, (3E)-3-{(2E,4E,6R)-1-hydroxy-4-methyl-6-[(1R,3R,4S,5R)-1,4,8-trimethyl-2,9-dioxabicyclo[3.3.1]non-7-en-3-yl]hepta-2,4-dien-1-ylidene}-2H-pyrrole-2,4(3H)-dione, ... (4 entities in total)
• Functional Keywords: p450, monooxygenase, oxidoreductase
• Biological source: Streptomyces sp. 307-9
• Total number of polymer chains: 8
• Total formula weight: 373712.21

Authors

Newmister, S.A.,Srivastava, K.R.,Espinoza, R.V.,Haatveit, K.C.,Khatri, Y.,Martini, R.M.,Garcia-Borras, M.,Podust, L.M.,Houk, K.N.,Sherman, D.H. (deposition date: 2020-06-03, release date: 2021-06-09, Last modification date: 2024-04-03)

• Primary citation: Newmister, S.A.,Srivastava, K.R.,Espinoza, R.V.,Haatveit, K.C.,Khatri, Y.,Martini, R.M.,Garcia-Borras, M.,Podust, L.M.,Houk, K.N.,Sherman, D.H.; Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway.; Acs Catalysis, 10:13445-13454, 2020; PubMed: 33569241; DOI: 10.1021/acscatal.0c03248

Experimental method

X-RAY DIFFRACTION (2.64 Å)