6X3J
Crystal structure of streptogramin A acetyltransferase VatA from Staphylococcus aureus in complex with streptogramin analog F0224 (46)
Summary for 6X3J
Entry DOI | 10.2210/pdb6x3j/pdb |
Related | 6X3C |
Descriptor | Virginiamycin A acetyltransferase,VatA, (2R)-2-[(3S,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-4,12-dimethyl-1,7,22-trioxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, PHOSPHATE ION, ... (7 entities in total) |
Functional Keywords | acetyltransferase, transferase |
Biological source | Staphylococcus aureus More |
Total number of polymer chains | 6 |
Total formula weight | 150224.51 |
Authors | Chaires, H.A.,Fraser, J.S. (deposition date: 2020-05-21, release date: 2020-11-18, Last modification date: 2023-10-18) |
Primary citation | Li, Q.,Pellegrino, J.,Lee, D.J.,Tran, A.A.,Chaires, H.A.,Wang, R.,Park, J.E.,Ji, K.,Chow, D.,Zhang, N.,Brilot, A.F.,Biel, J.T.,van Zundert, G.,Borrelli, K.,Shinabarger, D.,Wolfe, C.,Murray, B.,Jacobson, M.P.,Muhle, E.,Chesneau, O.,Fraser, J.S.,Seiple, I.B. Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586:145-150, 2020 Cited by PubMed: 32968273DOI: 10.1038/s41586-020-2761-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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