6WXL

Cryo-EM structure of the VRC315 clinical trial, vaccine-elicited, human antibody 1D12 in complex with an H7 SH13 HA trimer

Summary for 6WXL

Entry DOI	10.2210/pdb6wxl/pdb
EMDB information	21961
Descriptor	Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, 1D12 Light chain, ... (5 entities in total)
Functional Keywords	vrc, immune system, vrc315, group 2, fab
Biological source	Influenza A virus (A/Shanghai/JS01/2013(H7N9)) More
Total number of polymer chains	12
Total formula weight	329854.32
Authors	Gorman, J.,Kwong, P.D. (deposition date: 2020-05-11, release date: 2021-06-09, Last modification date: 2022-06-22)
Primary citation	Cheung, C.S.,Gorman, J.,Andrews, S.F.,Rawi, R.,Reveiz, M.,Shen, C.H.,Wang, Y.,Harris, D.R.,Nazzari, A.F.,Olia, A.S.,Raab, J.,Teng, I.T.,Verardi, R.,Wang, S.,Yang, Y.,Chuang, G.Y.,McDermott, A.B.,Zhou, T.,Kwong, P.D. Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite. Structure, 2022 Cited by PubMed: 35489332 DOI: 10.1016/j.str.2022.04.003 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.76 Å)

Structure validation