6WT4

Structure of a bacterial STING receptor from Flavobacteriaceae sp. in complex with 3',3'-cGAMP

Summary for 6WT4

• Entry DOI: 10.2210/pdb6wt4/pdb
• Descriptor: Bacterial STING, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: cbass, cyclic dinucleotide receptor, cd-ntase, immune effector, immune system
• Biological source: Flavobacteriaceae
• Total number of polymer chains: 2
• Total formula weight: 38205.29

Authors

Morehouse, B.R.,Govande, A.A.,Millman, A.,Keszei, A.F.A.,Lowey, B.,Ofir, G.,Shao, S.,Sorek, R.,Kranzusch, P.J. (deposition date: 2020-05-01, release date: 2020-09-09, Last modification date: 2020-10-28)

• Primary citation: Morehouse, B.R.,Govande, A.A.,Millman, A.,Keszei, A.F.A.,Lowey, B.,Ofir, G.,Shao, S.,Sorek, R.,Kranzusch, P.J.; STING cyclic dinucleotide sensing originated in bacteria.; Nature, 586:429-433, 2020; PubMed: 32877915; DOI: 10.1038/s41586-020-2719-5

Experimental method

X-RAY DIFFRACTION (1.78 Å)