6WRX

Crystal structure of computationally designed protein 2DS25.1 in complex with the human Transferrin receptor ectodomain

Summary for 6WRX

• Entry DOI: 10.2210/pdb6wrx/pdb
• Descriptor: Transferrin receptor protein 1, Computationally designed protein 2DS25.1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: complex, beta sheet, receptor, de novo protein, de novo protein-metal transport complex, de novo protein/metal transport
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 167017.81

Authors

Abraham, J.,Coscia, A.,Olal, D.,Sahtoe, D.D.,Baker, D.,Clark, L. (deposition date: 2020-04-30, release date: 2021-04-28, Last modification date: 2023-10-18)

• Primary citation: Sahtoe, D.D.,Coscia, A.,Mustafaoglu, N.,Miller, L.M.,Olal, D.,Vulovic, I.,Yu, T.Y.,Goreshnik, I.,Lin, Y.R.,Clark, L.,Busch, F.,Stewart, L.,Wysocki, V.H.,Ingber, D.E.,Abraham, J.,Baker, D.; Transferrin receptor targeting by de novo sheet extension.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33879614; DOI: 10.1073/pnas.2021569118

Experimental method

X-RAY DIFFRACTION (3.07 Å)