6WQU

CSL (RBPJ) bound to Notch3 RAM and DNA

Summary for 6WQU

• Entry DOI: 10.2210/pdb6wqu/pdb
• Descriptor: DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), Recombining binding protein suppressor of hairless, ... (5 entities in total)
• Functional Keywords: notch signaling, dna binding protein, transcription factor, activation complex, transcription, transcription-signaling protein-dna complex, transcription/signaling protein/dna
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 4
• Total formula weight: 59357.24

Authors

Kovall, R.A.,Gagliani, E.,Hall, D. (deposition date: 2020-04-29, release date: 2021-03-31, Last modification date: 2023-10-18)

• Primary citation: Landor, S.K.J.,Santio, N.M.,Eccleshall, W.B.,Paramonov, V.M.,Gagliani, E.K.,Hall, D.,Jin, S.B.,Dahlstrom, K.M.,Salminen, T.A.,Rivero-Muller, A.,Lendahl, U.,Kovall, R.A.,Koskinen, P.J.,Sahlgren, C.; PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion.; J.Biol.Chem., 296:100593-100593, 2021; PubMed: 33775697; DOI: 10.1016/j.jbc.2021.100593

Experimental method

X-RAY DIFFRACTION (2.41 Å)