6WPF

Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and d4T

Summary for 6WPF

Entry DOI	10.2210/pdb6wpf/pdb
Descriptor	DNA Primer 21-mer, DNA template 27-mer, Reverse transcriptase/ribonuclease H, ... (10 entities in total)
Functional Keywords	reverse transcriptase, ternary complex, d4t, chain terminator, stereochemistry, transferase, transferase-dna complex, stavudine, transferase/dna
Biological source	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) More
Total number of polymer chains	4
Total formula weight	133587.75
Authors	Bertoletti, N.,Anderson, K.S. (deposition date: 2020-04-27, release date: 2020-11-04, Last modification date: 2023-10-18)
Primary citation	Bertoletti, N.,Chan, A.H.,Schinazi, R.F.,Anderson, K.S. Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance. Molecules, 25:-, 2020 Cited by PubMed: 33096918 DOI: 10.3390/molecules25204868 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.53 Å)

Structure validation